Cytomegalovirus Pneumonitis in a Patient with Homozygous β-Thalassemia and Splenectomy

Japanese journal of infectious diseases

Konstantinos Fragkiadakis¹  Petros Ioannou²  John A. Papadakis³ 

[1] Department of Cardiology, University Hospital of Heraklion;Department of Internal Medicine, University Hospital of Heraklion;Department of Radiology, University Hospital of Heraklion

关键词: cytomegalovirus;    β-thalassemia;    splenectomy;    blood transfusion;    pneumonitis;   

DOI  :  10.7883/yoken.JJID.2018.039

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

Cytomegalovirus (CMV) rarely causes disease in immunocompetent individuals but may cause severe disease in immunocompromised patients. We report the case of a young woman who had undergone multiple transfusions and splenectomy for homozygous β-thalassemia. She presented with prolonged fever and respiratory distress. Although broad-spectrum antibiotic therapy had initially been administered, the patient had clinically deteriorated. Serology and molecular blood testing established CMV infection and viremia. Computed tomography of the chest demonstrated pneumonitis and she was successfully treated with a 3-week administration of ganciclovir. In β-thalassemia patients who undergo splenectomy necessitating multiple blood transfusions, CMV infection should be considered as a differential diagnosis.

【 授权许可】

Unknown