Epidemiology and Molecular Detection of HAV, HBV, and HCV in Patients with Acute Hepatitis Symptoms in Ahvaz

Jundishapur Journal of Microbiology

Manoochehr Makvandi¹  Maryam Tabasi²  Ali Teimoori³ 

[1] Department of Epidemiology and Biostatistics, Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;Pasteur Laboratory, Ahvaz, Iran

关键词: Epidemiology and Molecular Detection of HAV;    HBV;    and HCV in Patients with Acute Hepatitis Symptoms in Ahvaz;    Hepatitis A Virus (HAV);    Hepatitis B Virus (HBV);    Hepatitis C Virus (HCV);    Molecular Epidemiology;    Risk Factor;    Polymerase Chain Reaction;    Tattooing;   

DOI  :  10.5812/jjm.63317

学科分类：微生物学和免疫学

来源: Jundishapur Journal of Microbiology

【 摘 要 】

Viral hepatitis has emerged as a major public health problem leading to disproportionate degrees of morbidity and mortality worldwide.This study describes epidemiology of hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV), and associated risk factors in patients with acute hepatitis symptoms in southwest of Iran (Ahvaz).A total of 150 serum samples from patients with elevated serum aminotransferase levels were subjected to serological and molecular assays.The sero-prevalence of HAV, HBV, and HCV was 79.3%. Furthermore, HAV, HBV, and HCV nucleic acids were detected in 28%, 18.7%, and 22.7% of samples, respectively. All HAV cases were categorized in the IB genotype and HBV isolates belonged to genotype D. Hepatitis C virus RNA-positive samples were clustered in genotypes 1a (38.3%) and 3a (61.7%). The authors found that some risk factors, such tattooing and traveling to endemic areas, had a crucial role in rising of viral hepatitis frequency in Ahvaz city.These results document the prevalence of circulating viral hepatitis in Ahvaz city and may draw attention to the necessity for a comprehensive program to control viral hepatitis in this region.

【 授权许可】

CC BY-NC