4G-β-D-galactosylsucrose as a prebiotics may improve underweight in inpatients with schizophrenia

Bioscience of Microbiota, Food and Health

Yumiko IDO¹  Masaru NAKAMURA²  Takehiko OKAMURA³  Takahiko NAGAMINE⁴ 

[1] Department of Health and Nutrition, Baika Women’s University, Ibaraki, Osaka, Japan;Koseikai-Kusatsu Hospital, Hiroshima, Japan;Osaka Institute of Psychiatry, Shin-Abuyama Hospital, Osaka, Japan;Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu City, Yamaguchi 747-0066, Japan

关键词: underweight;    schizophrenia;    4G-β-D-galactosylsucrose;    Bifidobacterium;   

DOI  :  10.12938/bmfh.17-016

学科分类：生物科学（综合）

来源: Nihon Bifizusukin Senta / Japan Bifidus Foundation

【 摘 要 】

Japanese inpatients with schizophrenia have a higher mortality risk due to underweight compared with the general population. The aim of this study was to investigate the effect of 4G-β-D-galactosylsucrose on body weight in underweight schizophrenia inpatients. The study population consisted of 5 male and 11 female subjects aged 63.0 ± 10.9 years. The subjects had ingested 3.0 g/day 4G-β-D-galactosylsucrose for 6 months. BMI increased significantly, from 20.9 ± 3.7 kg/m2 to 22.3 ± 4.3 kg/m2, and this was accompanied by a significant increase in Bifidobacterium in the fecal microbiota, which increased from 16.1 ± 12.6% to 21.5 ± 13.9%. Although 4G-β-D-galactosylsucrose appears to have no significant effects on nutritional indicators such as serum albumin, it may alleviate underweight in inpatients with schizophrenia. Body weight may be related to fecal microbiota composition.

【 授权许可】

CC BY