MixProTool: A Powerful and Comprehensive Web Tool for Analyzing and Visualizing Multigroup Proteomics Data

Journal of computational biology: A journal of computational molecular cell biology

WenZheng^1¹  ShishengWang^1²  LiqiangHu^1³ 

[1] Address correspondence to:Prof. Meng GongLab of Proteomics and MetabolomicsWest China-Washington Mitochondria and Metabolism Research CenterKey Lab of Transplant Engineering and Immunology, MOHWest China Hospital, SCUNo. 88, Keyuan South RoadHi-tech Zone, Chengdu 610041, China^2;Lab of Proteomics and Metabolomics, West China-Washington Mitochondria and Metabolism Research Center, Key Lab of Transplant Engineering and Immunology, MOH, West China Hospital, SCU, Chengdu, China^1;Prof. Hao YangLab of Proteomics and MetabolomicsWest China-Washington Mitochondria and Metabolism Research CenterKey Lab of Transplant Engineering and Immunology, MOHWest China Hospital, SCUNo. 88, Keyuan South RoadHi-tech Zone, Chengdu 610041, China^3

关键词: multigroups;    proteomics data;    web tool;    data analysis workflow.;   

DOI  :  10.1089/cmb.2018.0050

学科分类：生物科学（综合）

来源: Mary Ann Liebert, Inc. Publishers

【 摘 要 】

Deciphering and visualizing proteomics data are a big challenge for high-throughput proteomics research. In this work, we develop a free interactive web software platform, MixProTool, for processing multigroup proteomics data sets. This tool provides integrated data analysis workflow, including quality control assessment, normalization, soft independent modeling of class analogy, statistics, gene ontology enrichment, and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. This software is also highly compatible with the identification and quantification results of various frequently used search engines, such as MaxQuant, Proteome Discoverer, or Mascot. Moreover, all analyzed results can be visualized as vector graphs and tables for further analysis. MixProTool can be conveniently operated by users, even those without bioinformatics training, and it is extremely useful for mining the most relevant features among different samples. MixProTool is deployed at the public shinyapps io server.

【 授权许可】

Unknown