Pre-treatment partial-volume-corrected TLG is the best predictor of overall survival in patients with relapsing/refractory non-hodgkin lymphoma following radioimmunotherapy

American Journal of Nuclear Medicine and Molecular Imaging

Siavash Mehdizadeh Seraj¹  Mahdi Zirakchian Zadeh²  Raheleh Taghvaei³  William Y Raynor⁴  Sara Pourhassan Shamchi⁵  Reza Sirous⁶ 

[1] Department of Dermatology, Hospital of The University of Pennsylvania, PA, USA;Department of Radiology, Childrens Hospital of Philadelphia, PA, USA;Department of Radiology, Hospital of The University of Pennsylvania, PA, USA;Department of Radiology, Stanford University Medical Center, Stanford, CA, USA;Drexel University College of Medicine, Philadelphia, PA, USA;University of Maryland Medical Center, Baltimore, MD, USA

关键词: Positron emission tomography;    FDG;    radioimmunotherapy;    relapsing/refractory non-hodgkin lymphoma;    global disease assessment;    partial volume correction;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

The role of fluorodeoxyglucose-positron emission tomography (FDG-PET) has been well established in assessment of lymphoma, including non-Hodgkin lymphoma (NHL). The aim of this study was to compare changes and survival predictive values of various quantification parameters of FDG-PET/CT in patients with relapsing/refractory lymphoma before and after radioimmunotherapy (RIT). Data from 17 patients with relapsing/refractory NHL, treated with targeted RIT after chemotherapy/radiotherapy, were retrospectively collected. FDG-PET/CT scans were performed approximately three months before and six months after RIT. An adaptive contrast-oriented thresholding algorithm was used to segment lesions on the FDG-PET images. Wilcoxon signed-rank tests were used to assess changes in SUVmax, SUVmean, partial volume-corrected SUVmean (pvcSUVmean), total lesion glycolysis (TLG), and pvcTLG before and after treatment. The patients were followed up after completing RIT for up to 10 years. Kaplan-Meier and Cox regression analyses evaluated the association between the quantification parameters and survival data. In the survived group, the decrease in mean percentage of change for TLG and pvcTLG was greater than SUVmax, SUVmean and pvcSUVmean [TLG: 253.9 to 106.9, -81.4%; P = 0.052 and pvcTLG: 368.9 to 153.3, -58.4%; P = 0.04]. In addition, overall survival (OS) was shorter in patients with pre-RIT pvcTLG more than 644 compared to those below this value (log-rank P < 0.01). In univariate Cox regression for OS, a higher baseline pvcTLG was a significant prognostic factor (HR: 6.8, P = 0.02). Our results showed that pre-treatment pvcTLG was the best predictor of OS in patients with relapsing/refractory NHL following RIT.

【 授权许可】

CC BY-NC