Brain metastases in non-small-cell lung cancer: are tyrosine kinase inhibitors and checkpoint inhibitors now viable options?

Current oncology

A. Wong¹  S. Morin-Ben Abdallah² 

[1] Hôpital du Suroît;McGill University Health Centre

关键词: Non-small-cell lung cancer;    nsclc;    epidermal growth factor receptor;    EGFR;    tyrosine kinase inhibitors;    tkis;    afatinib;    osimertinib;    ALK;    crizotinib;    alectinib;    ceritinib;    immunotherapy;    nivolumab;    pembrolizumab;   

DOI  :  10.3747/co.25.3733

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

Significant progress has been made in the treatment of stage iv non-small-cell lung cancer (nsclc); however, the prognosis of patients with brain metastases remains poor. Resection and radiation therapy remain standard options. This issue is an important one because 10% of patients with nsclc have brain metastases at diagnosis, and 25%–40% develop brain metastases during their disease. Standard chemotherapy does not cross the blood–brain barrier. However, there is new hope that tyrosine kinase inhibitors (tkis) used in patients with identified targetable mutations such as mutations ofEGFRand rearrangements ofALKcould have activity in the central nervous system (cns). Furthermore, immunotherapy is increasingly becoming a standard option for patients with nsclc, and interest about the intracranial activity of those agents is growing. This review presents current data about the cns activity of the available major tkis and immunotherapy agents.

【 授权许可】

Unknown