Sequence analysis of the cDNA encoding for SpCTx: a lethal factor from scorpionfish venom (Scorpaena plumieri)

Journal of Venomous Animals and Toxins including Tropical Diseases

Fábio L. S. Costa¹  Maria Elena De Lima² 

[1]Universidade Federal de Minas Gerais

[2]Universidade Federal do Espírito Santo

关键词: cDNA;    Lethal factor;    Scorpaena plumieri;    Scorpionfish;    Venom gland;   

DOI  :  10.1186/s40409-018-0158-7

学科分类：过敏症与临床免疫学

来源: SciELO

【 摘 要 】

BackgroundLethal factors are multifunctional oligomeric proteins found in the venomous apparatus of Scorpaeniformes fish. These toxins elicit not only an array of biological responses in vitro but also cardiovascular disorders and strong hemolytic, nociceptive and edematogenic activities in vivo. This work describes the cloning and molecular identification of two toxin subunits, denominated Sp-CTx-α and Sp-CTx-β, from scorpionfish venom (Scorpaena plumieri).

【 授权许可】

CC BY