Umbilical cord mesenchymal stem cell (UC-MSC) transplantations for cerebral palsy

American Journal of Translational Research

Gang Li¹  Huipeng Meng²  Yuechen Luo³  Huajiang Dong⁴  Huijuan Yin⁵  Chongzhi Shang⁶ 

[1] Laser Medicine Laboratory, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences Peking Union Medical College, Tianjin 300192, China;Shulan (Hangzhou) Hospital, Hangzhou, China;State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China;State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China;The Department of Neurology and Neurosurgery, Affiliated Hospital of Logistics University of Chinese Peoples Armed Police Forces, Tianjin, China;Tianjin Key Laboratory of Neurotrauma Repair, Tianjin, China

关键词: Cerebral palsy;    umbilical cord;    mesenchymal stem cell;    transplantation;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

This study reports a case of a 4-year-old boy patient with abnormalities of muscle tone, movement and motor skills, as well as unstable gait leading to frequent falls. The results of the electroencephalogram (EEG) indicate moderately abnormal EEG, accompanied by irregular seizures. Based on these clinical characteristics, the patient was diagnosed with cerebral palsy (CP) in our hospital. In this study, the patient was treated with umbilical cord mesenchymal stem cell (UC-MSC) transplantation therapy. This patient received UC-MSC transplantation 3 times (5.3*107) in total. After three successive cell transplantations, the patient recovered well and showed obvious improvements in EEG and limb strength, motor function, and language expression. However, the improvement in intelligence quotient (IQ) was less obvious. These results indicate that UC-MSC transplantation is a promising treatment for cerebral palsy.

【 授权许可】

CC BY-NC