The expression of PD-1 and LAG-3 in periapical lesions

American Journal of Translational Research

Fu-Hua Yang¹  Yuan Li²  Hai-Sheng Wang³ 

[1] Department of Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China;Functional Genomics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA;The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education [KLOBM]), School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China

关键词: Periapical lesions;    inflammation;    programmed cell death protein 1 (PD-1);    lymphocyte activating gene 3 (LAG-3);   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Periapical lesions are the distinct result of chronic root canal infection and could generate severe bone resorption surrounding apical regions. Despite the local cytokine and cell-mediated immune responses, periapical lesions are also characterized by its auto-restrict inflammation. However, the detailed mechanism related to its auto-restriction of immune response is still unclear. Co-inhibitory immune checkpoints are important molecules which could negatively modulate immune response especially in T cell function. In this study we detected the expressional pattern of PD-1/LAG-3 in periapical lesions. Immunohistochemical staining showed that the inflammatory response including up-regulation of TNF-α and the infiltration of T cells, was severe in granuloma and restricted in periapical cyst. PD-1 and LAG-3 both could be detected in granuloma and cyst, while scarcely observed in control group. Exhausted T cells, characterized by PD-1 or LAG-3 positive, accumulated within granuloma and reduced in cyst. Our study revealed that in periapical lesions, T cell exhaustion characterized by PD-1 or LAG-3 positive, might contribute to the auto-restriction of inflammatory response in periapical lesions.

【 授权许可】

CC BY-NC