Invasive Fungal Infection Caused by Geotrichum clavatum in a Child with Acute Leukemia: First Documented Case from Mainland China

Japanese journal of infectious diseases

Xingxin Liu¹  Wei Zhou² 

[1] Department of Laboratory Medicine, West China Second University Hospital, Sichuan University;Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education

关键词: invasive fungal infections;    Geotrichum clavatum;    chemotherapy;    leukemia;   

DOI  :  10.7883/yoken.JJID.2018.351

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

Invasive fungal infections are one of the vital complications among acute leukemia patients undergoing induction chemotherapy. Among them, Geotrichum clavatum infections present extremely rarely with atypical clinical symptoms which make them difficult to diagnose. In this paper, we report a case of infection caused by Geotrichum clavatum in a 10-year old child with acute leukemia, which is the first documented case from mainland China. With underlying childhood leukemia, the child suffered from recurrent bacterial and fungal infection and even underwent abdominal surgery during the treatment. Fortunately, the therapeutic effect was finally achieved by adjusting the treatment program to dual anti-fungal treatment with micafungin and amphotericin B. Information regarding the epidemiological, clinical, and therapeutic features, in this case, shows significant perspectives for anti-fungal treatment for immunocompromised individuals, wherefore the rate of recovery and survival can be achieved.

【 授权许可】

Unknown