Long non-coding RNA SNHG7 promotes the fracture repair through negative modulation of miR-9

American Journal of Translational Research

Han Jiang¹  Zhiqing Chen³  Zhi Liu⁴  Lin Shen⁵ 

[1] Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China;Department of Osteology, Tianjin Hospital, Tianjin 300210, China;Department of Osteology, Tianjin Third Central Hospital, Tianjin 300170, China;Tianjin Institute of Hepatobiliary Disease, Tianjin 300170, China;Tianjin Key Laboratory of Artificial Cell, Tianjin 300170, China

关键词: Femoral neck fracture;    osteoblast cells;    SNHG7;    miR-9;    TGF-β;    signaling pathway;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Fracture is the most common disease in the orthopedics. Long non-coding small nucleolar RNA host gene 7 (SNHG7) has been confirmed to enhance cell proliferation and decrease cell apoptosis in many cancers. However, the role of SNHG7 in skeletal fracture remains largely to be elucidated. In the current study, we observed SNHG7 was down-regulated in femoral neck fracture tissues. In addition, SNHG7 knockdown inhibited proliferation and migration, induced apoptosis, reduced activity in osteoblast cells in vitro. Bioinformatics analysis revealed SNHG7 acts as a molecular sponge for miR-9 and MiR-9 directly targets with 3’-UTR of TGFBR2. Furthermore, SNHG7 knockdown repressed the TGF-β signaling pathway. Taken together, this study manifested SNHG7 promotes bone repair in femoral neck fracture, and may serve as a potential target for enhancing bone formation.

【 授权许可】

CC BY-NC