Surveillance of Antibiotic Susceptibility Patterns of Neisseria gonorrhoeae from 2013 to 2015 in Guangxi Province, China

Japanese journal of infectious diseases

Quan Gan¹  Shao He²  Wei Li³  Ming Liang⁴  Huai-zhong Chen⁵  Bang-yong Zhu⁶  Shui-qing Qin⁷  Mao-chun Yang⁸ 

[1] Peking Union Medical College;Beihai People’s Hospital;Guangxi Institute of Dermatology;Guigang Institute of Dermatology;Institute of Dermatology, Chinese Academy of Medical Sciences &Nanning Blood Center;The First Affiliated Hospital of Guangxi Medical University;Yulin Institute of Dermatology

关键词: Neisseria gonorrhoeae;    antibiotic susceptibility;    resistance;    ciprofloxacin;    azithromycin;   

DOI  :  10.7883/yoken.JJID.2017.169

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

Neisseria gonorrhoeae is a sexually transmitted pathogen highly prevalent worldwide with an increasing trend of resistance to antimicrobial treatment. We conducted this study to trace the susceptibility of N. gonorrhoeae to penicillin (PC), spectinomycin (SPCM), ciprofloxacin (CPFX), azithromycin (AZM), cefixime (CFIX), and ceftriaxone (CTRX) in Guangxi province. In total, 303 N. gonorrhoeae isolates were obtained from patients infected with N. gonorrhoeae in 6 cities in Guangxi during 2013–2015, and the antibiotic susceptibility patterns were analyzed by an agar dilution assay. The results showed that N. gonorrhoeae was susceptible to treatment with cephalosporins, including CTRX (99.7% of isolates), CFIX (99%), SPCM (100%), and AZM (96.4%), and this is the first report of antibiotic susceptibility for AZM surveillance of N. gonorrhoeae in Guangxi. Penicillinase-producing N. gonorrhoeae (PPNG) isolates increased in prevalence from 37% in 2013 to 64% in 2015 (P = 0.068), and tetracycline-resistant N. gonorrhoeae (TRNG) prevalence increased from 23% in 2013 to 44% in 2015 (P = 0.071). High resistance of N. gonorrhoeae to PC was associated with infection in patients at ages 25 to 30 years (P ＜ 0.05), whereas PPNG positivity (P ＜ 0.01), and TRNG positivity were risk factors for CPFX resistance (P = 0.0407). Our study provides plausible evidence for therapeutic strategies and N. gonorrhoeae infection control and prevention in Guangxi, China.

【 授权许可】

Unknown