Impact of white matter changes on neurologic outcomes of total arch replacement using antegrade cerebral perfusion

The Journal of Thoracic and Cardiovascular Surgery

Yuki Ikeno¹  Koji Sasaki² 

[1] Department of Cardiovascular Surgery, Kobe University, Kobe, Japan;Department of Radiology, Kobe University, Kobe, Japan

关键词: aortic arch surgery;    total arch replacement;    perioperative care;    magnetic resonance image;    postoperative stroke;   

DOI  :  10.1016/j.jtcvs.2018.10.150

学科分类：心脏病和心血管学

来源: Mosby, Inc.

【 摘 要 】

ObjectiveTo evaluate the impact of white matter changes on neurologic outcomes after total arch replacement using antegrade cerebral perfusion.MethodsWhite matter changes were assessed using a visual Fazekas scale on preoperative magnetic resonance images. From October 1999 to December 2016, 359 patients who had demonstrated changes on preoperative magnetic resonance imaging underwent elective total arch replacement using antegrade cerebral perfusion. Patients were classified into 3 severity groups: mild (100 patients), moderate (158 patients), and severe (101 patients). Mean follow-up time was 4.8 ± 3.6 years. Multivariate logistic regression methods were used to evaluate for an independent association between white matter changes and postoperative neurological outcomes.ResultsHospital mortality was 2.8% (10/359), and no significant differences were found across the 3 groups (P = .604). Multivariate analysis demonstrated that the severity of white matter change was significantly associated with both postoperative permanent neurologic deficit (odds ratio, 5.77; 95% confidence interval, 1.58-38.4, P = .005) and transient neurologic deficit (odds ratio, 2.46; 95% confidence interval, 1.45-4.37, P ConclusionsWhite matter changes, defined using the visual Fazekas scale on preoperative magnetic resonance imaging, were significantly associated with significant postoperative adverse neurologic outcomes after total arch replacement using antegrade cerebral perfusion.

【 授权许可】

Unknown