Real-world benefit of nivolumab in a Canadian non-small-cell lung cancer cohort

Current oncology

J. Villeneuve¹  N. Finn²  F. Romeyer³  C. Labbé⁴  R. A. Juergens⁵  S. Owen⁶  F. A Shepherd⁷  J. Rothenstein⁸  J. Jolivet⁹  C. Mariano^1,10  M. N. Reaume^1,11  A. Faghih^1,12 

[1]Bristol–Myers Squibb

[2]Centre hospitalier universitaire Dr-Georges-L.-Dumont

[3]Cross Cancer Institute

[4]Institut universitaire de cardiologie et de pneumologie de Québec

[5]Juravinski Cancer Centre

[6]McGill University Health Centre

[7]Princess Margaret Cancer Centre

[8]R.S. McLaughlin Durham Regional Cancer Centre

[9]Recherche médicale Saint-Jérôme Inc.

[10]Royal Columbian Hospital

[11]The Ottawa Hospital Cancer Centre

[12]Thunder Bay Regional Health Sciences Centre

关键词: Nivolumab;    non-small-cell lung cancer;    real-world data;    duration of treatment;    overall survival;   

DOI  :  10.3747/co.25.4287

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

BackgroundNivolumab was the first immuno-oncology agent available for the treatment of lung cancer in Canada. In the present study, we evaluated the real-world benefit of nivolumab in Canadian patients with lung cancer. MethodsPatients included in the cohort were identified from a registry of patients treated through expanded access to nivolumab before and after Health Canada approval. Demographics were collected from the application forms. Outcome data for the duration of treatment and survival were collected retrospectively. ResultsIn contrast to the randomized clinical trial populations, our study cohort included patients who were older (median age: 66 years; range: 36–92 years) and who had an Eastern Cooperative Oncology Group performance status of 2 (8.9%). Despite the poorer-prognosis cohort, median overall survival was 12.0 months, which is comparable to the survival demonstrated in the randomized phase iii trials of nivolumab in lung cancer. Median time to treatment discontinuation was 3.45 months and was similar for all patient subgroups, including poorer-prognosis groups such as those with a performance status of 2, those 75 years of age and older, and those with brain metastases. ConclusionsNivolumab given in a real-world clinical setting was associated with results similar to those reported in the phase iii clinical trial setting.

【 授权许可】

Unknown