Long noncoding RNA AFAP1-AS1 facilitates tumor growth through enhancer of zeste homolog 2 in colorectal cancer

American Journal of Cancer Research

Haiyan Chen¹  Jianhui Wu²  Jianming Tang³  Guansheng Zhong⁴ 

[1] Department of Otolaryngology, Meizhou Peoples Hospital, Meizhou 514000, Guangdong, P. R. China;Department of Radiation Oncology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, P. R. China;Department of Radiation Oncology, Zhejiang Provincial Peoples Hospital, Peoples Hospital of Hangzhou Medical College, Hangzhou 310009, Zhejiang, P. R. China;Department of Thyroid and Breast Surgery, Zhejiang Provincial Peoples Hospital, Peoples Hospital of Hangzhou Medical College, Hangzhou 310009, Zhejiang, P. R. China

关键词: lncRNA;    AFAP1-AS1;    EZH2;    colorectal cancer;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

Increasing evidences have shown that long noncoding RNAs (lncRNAs) play critical regulatory roles in cancer biology. However, the contributions of lncRNAs to colorectal cancer remain largely unknown. Here, we identify a lncRNA AFAP1-AS1 that facilitates colorectal cancer, where it is upregulated. AFAP1-AS1 expression was associated with colorectal cancer patient survival. AFAP1-AS1 knockdown inhibited cell proliferation, cell cycle, and tumorigenesis in an subcutaneous mouse xenograft model system. Further data demonstrated that AFAP1-AS1 was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of EZH2 target genes. Our findings indicate that AFAP1-AS1 is an oncogenic lncRNA that promotes tumor progression and may be a novel prognostic factor in colorectal cancer. Targeting AFAP1-AS1 might be a potential therapeutic strategy for colorectal cancer treatment.

【 授权许可】

CC BY-NC