Long Non-Coding RNA SNHG6 as a Potential Biomarker for Hepatocellular Carcinoma

Pathology oncology research: POR

Zahra Shoja¹  Maryam Tahmasebi Birgani²  Atefeh Khoshnevisan³  Mohammadreza Hajjari⁴  Arman Shahrisa⁵  Paria Motahari⁶ 

[1] Technology;Ahvaz Jundishapur University of Medical Sciences;Iranian Research Organization Science &Shahid Chamran University of Ahvaz;Tarbiat Modares University;Tehran University of Medical Sciences

关键词: Hepatocellular carcinoma;    Biomarker;    Long noncoding RNA;    SNHG6;    Systematic analysis;   

DOI  :  10.1007/s12253-017-0241-3

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

Long Non-coding RNAs (lncRNAs) refer to all non-protein coding transcripts longer than 200 nucleotides. Their critical roles in different biological pathways have been already well established. Altered expression of lncRNAs can be involved in the cancer initiation and/or progression. Since patients with hepatocellular carcinoma (HCC) are usually diagnosed in late stages, developing diagnostic methods seems to be essential. In this study, the expression levels of different lncRNAs were systematically analysed in different genomic and transcriptome datasets. The analyses showed that SNHG6 is among the lncRNAs with distinctive dysregulation of expression and copy number variation in HCC tumors compared with normal tissues. The results also suggest that the dysregulation of SNHG6 is highly cancer type specific. Through co-occurrence analyses, we found that SNHG6 and its related co-expressed genes on 8q are involved in the structural integrity of ribosome and translation. This comprehensive in silico analysis, provides a resource for investigating SNHG6 in hepatocellular carcinoma and lays the groundwork for design of next researches.

【 授权许可】

CC BY