FGF signaling: diverse roles during cochlear development

BMB Reports

Sung-Ho Huh^1,2²  Michael Ebeid^2³ 

[1] Department of Developmental Neuroscience, Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, Nebraska, USA^3;Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, USA^2;Mary &^1

关键词: Cochlea;   

DOI  :  10.5483/BMBRep.2017.50.10.164

学科分类：生物化学/生物物理

来源: Korean Society for Biochemistry and Molecular Biology

【 摘 要 】

Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development.

【 授权许可】

Unknown