Prediction of Central Nervous System Side Effects Through Drug Permeability to Blood–Brain Barrier and Recommendation Algorithm

Journal of computational biology: A journal of computational molecular cell biology

JingYang^2¹  JunFan^1,2² 

[1] Department of Computer Science and Technology, East China Normal University, Shanghai, China^2;Shanghai Key Laboratory of Multidimensional Information Processing, East China Normal University, Shanghai, China^1

关键词: blood–brain barrier;    central nervous system;    drug side effects;    recommender system;   

DOI  :  10.1089/cmb.2017.0149

学科分类：生物科学（综合）

来源: Mary Ann Liebert, Inc. Publishers

【 摘 要 】

Drug side effects are one of the public health concerns. Using powerful machine-learning methods to predict potential side effects before the drugs reach the clinical stages is of great importance to reduce time consumption and protect the security of patients. Recently, researchers have proved that the central nervous system (CNS) side effects of a drug are closely related to its permeability to the blood–brain barrier (BBB). Inspired by this, we proposed an extended neighborhood-based recommendation method to predict CNS side effects using drug permeability to the BBB and other known features of drug. To the best of our knowledge, this is the first attempt to predict CNS side effects considering drug permeability to the BBB. Computational experiments demonstrated that drug permeability to the BBB is an important factor in CNS side effects prediction. Moreover, we built an ensemble recommendation model and obtained higher AUC score (area under the receiver operating characteristic curve) and AUPR score (area under the precision-recall curve) on the data set of CNS side effects by integrating various features of drug.

【 授权许可】

Unknown