The contrasting roles of inflammasomes in cancer

American Journal of Cancer Research

Qin He¹  Yu Fu² 

[1] Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong Univsersity of Science and Technology, Wuhan, China;Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

关键词: Inflammasomes;    cancer;    tumor microenvironment;    immune system;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

Chronic inflammation plays a decisive role at different stages of cancer development. Inflammasomes are oligomeric protein complexes activated in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). PAMPs and DAMPs are released from infected cells, tumors and damaged tissues. Inflammasomes activate and release inflammatory cytokines such as IL-1β and IL-18. The various inflammasomes and inflammatory cytokines and chemokines play contrasting roles in cancer development and progression. In this review, we describe the roles of different inflammasomes in lung, breast, gastric, liver, colon, and prostate cancers and in glioblastomas.

【 授权许可】

CC BY-NC