Some Systemic Effects of Deuterium Depleted Water on Presenile Female Rats

Jundishapur Journal of Natural Pharmaceutical Products

Alexandr Alexandrovich Basov¹  Alla Ivanovna Shikhliarova²  Stepan Sergeevich Dzhimak³  Oleg Ivanovich Kit⁴  Galina Vitalievna Zhukova⁵ 

[1] Department of Fundamental and Clinical Biochemistry, Kuban State Medical University, Krasnodar, Russia;Department of Radiophysics and Nanotechnology, Kuban State University, Krasnodar, Russia;Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin, V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia;MTK Iceberg, LLC, Moscow, Russia;Testing Laboratory Centre, Rostov Research Institute of Oncology, Rostov-on-Don, Russia

关键词: Some Systemic Effects of Deuterium Depleted Water on Presenile Female Rats;    Deuterium;    NMR Spectroscopy;    Geroprotector Effect;    Anti-Stress Effect;    Anti-Stress Adaptation;    articles;    83494;   

DOI  :  10.5812/jjnpp.83494

学科分类：药理学

来源: Jundishapur Journal of Natural Pharmaceutical Products

【 摘 要 】

Consumption of deuterium depleted water (DDW) (46 ± 2 ppm) as drinking water by white outbred female rats (20 - 22 months) during five weeks led to the development of a well-pronounced geroprotector effect, which manifested in occurrence of the estrous cycle restoration signs, as well as in the coat state improvement, compared with the same characteristics of animals that received drinking water with a deuterium content of 150 ppm. Besides, rats receiving DDW showed the improvement of the skin bactericidal power. Thus, experiments in mammals provided a direct confirmation of the geroprotector properties of DDW. The current study revealed a deuterium content reduction in blood (according to the NMR (nuclear magnetic resonance) spectroscopy data) and visceral organs: liver, kidney, and heart (according to the mass spectroscopy data) in animals receiving DDW. A more pronounced decrease in the deuterium content was recorded in the rat blood plasma (33.2%) compared with the deuterium content changes in visceral organs (liver -7.2%, kidney -9.7%, heart -7.3%), which generally led to a change in the direction of the D/H isotopic gradient with consumption of DDW by the animals (CDblood plasma < CDvisceral organs).

【 授权许可】

CC BY-NC