On the preparation and characterization of superparamagnetic nanoparticles with Gelidium robustum agar coating for biomedical applications

Bulletin of Materials Science

JUAN JOSÉ ALVARADO-GIL^2¹  ARTURO I MARTÍNEZ^3²  DIANELA DÍAZ-BLEIS^1³  YOLANDA GÓMEZ-Y-GÓMEZ^4⁴ 

[1] Applied Physics Department, CINVESTAV-Mérida, Antigua Carretera a Progreso Km. 6, A.P. 97310 Mérida, Yucatán, Mexico^2;CINVESTAV-Saltillo, Av. Industria Metalúrgica 1062, Parque Industrial Ramos Arizpe, 25900 Coahuila, Mexico^3;Marine Resources Department, CINVESTAV-Mérida, Antigua Carretera a Progreso Km. 6, A.P. 97310 Mérida, Yucatán, Mexico^1;Pharmacology Laboratory, Instituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología, Av. Acueducto s/n Barrio La Laguna, Ticomán Del. Gustavo A. Madero, Mexico, Mexico^4

关键词: Agar;    superparamagnetic nanoparticles;    magnetite;    cobalt ferrite.;   

DOI  :  

学科分类：材料工程

来源: Indian Academy of Sciences

【 摘 要 】

Superparamagnetic nanoparticles coated with natural polysaccharides are of great interest for biomedical applications due to their fast response to an external and high-frequency electromagnetic field and their biocompatibility. One of the greatest challenges in the development of these nanoparticles is related to the specific characteristics and properties of the polysaccharide used, which could guarantee the development of specific sizes, crystalline structure, magneticresponse and its reproducibility. In this study, we present the preparation of magnetite (Fe$_3$O$_4$) and cobalt ferrite (CoFe$_2$O$_4$) nanoparticles by the co-precipitation method in aqueous solutions at different concentrations (1, 2, 3, 4 and 5%) of a very well-characterized agar obtained from the red marine algae Gelidium robustum. It is shown that under the same experimental conditions and using the adequate precursors, coated high-crystallinity magnetite nanoparticles are obtained. In contrast, for cobalt ferrite, our results indicated the formation of coated low-crystallinity CoFe$_2$O$_4$ particles. Superparamagnetic nanoparticles (with crystal grain size <8 nm) of Fe$_3$O$_4$ agar coated at >3% agar showed high-saturation magnetization and high degree of biocompatibility and can be considered as promising candidates for biomedical applications.

【 授权许可】

CC BY