Naloxegol hydrogen oxalate displaying a hydrogen-bonded layer structure

Acta Crystallographica Section E: Crystallographic Communications

Langes, C.¹  Gelbrich, T.² 

[1] Sandoz GmbH, Biochemiestrasse 10, 6250 Kundl, Austria;University of Innsbruck, Institute of Pharmacy, Innrain 52, 6020 Innsbruck, Austria

关键词: CRYSTAL STRUCTURE;    HYDROGEN BONDING;    TOPOLOGY;    OXALATE;    PHARMACEUTICALS;   

DOI  :  10.1107/S2056989018003675

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

In the salt (5α,6α)-6-[(2,5,8,11,14,17,20-hepta­oxadocosan-22-yl)­oxy]-3,14-dihy­droxy-17-(prop-2-en-1-yl)-4,5-ep­oxy­morphinan-17-ium hydrogen oxalate, C34H54NO11+·C2HO4− the polyether unit of the naloxegol cation adopts the shape of a squashed open letter `O'. In the crystal, the hydrogen oxalate anions are linked into a chain by O—H⋯O hydrogen bonds. Each naloxegol unit is hydrogen bonded to three hydrogen oxalate ions via two O—H⋯O and one N—H⋯O inter­actions. The resulting hydrogen-bonded two-dimensional layer structure is 3,5-connected and has the 3,5 L50 topology.

【 授权许可】

CC BY