Tumor suppressive role of rottlerin in cancer therapy

American Journal of Translational Research

Xueqiong Zhu¹  Yingying Hou²  Jun Xia³  Jia Ma⁴  Z Peter Wang⁵ 

[1] Center of Scientific Research, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China;Chinese Academy of Sciences Shanghai Institute of Materia Medica, Shanghai 201203, China;Departmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China;Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical College, Bengbu 233030, Anhui, China;Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

关键词: Rottlerin;    cancer;    therapy;    target;    antitumor;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Cancer as a major public health problem is a big trouble to be cured at present in the world. Thus, it is essential to discover better anticancer drugs to treat cancer patients. It has been reported that rottlerin, a natural polyphenolic compound from the mature fruits of Mallotus philippinensis, possesses multiple anti-cancer biological activities. Rottlerin exhibited its antitumor property in a variety of human cancers, suggesting that rottlerin could be a potential agent for treating cancers. In this review we discuss the recent literature regarding the biological functions and tumor suppressive mechanisms of rottlerin in cancers. We hope rottlerin will be further exploited for potential treatment of human cancers.

【 授权许可】

CC BY-NC