Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination

Tropical Medicine and Infectious Disease

Landry, Jasmine¹  Karanja, Diana M. S.²  Kavere, Emmy³  Korir, Harrison K.⁴  Ndombi, Eric M.⁵  Secor, W. Evan⁶  Kittur, Nupur⁷  Ondigo, Bartholomew N.⁸  Omondi, Amos⁹  Riner, Diana K.^1,10 

[1] Albany Medical College, Albany, NY 12208, USA;Author to whom correspondence should be addressed;Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA;Centre for Global Health Research, Kenya Medical Research Institute, Kisumu 40100, Kenya;Department of Biochemistry and Molecular Biology, Egerton University, Nakuru 20115, Kenya;Department of Microbiology, University of Georgia, Athens, GA 30602, USA;Department of Pathology, Kenyatta University, Nairobi 00609, Kenya;Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA;Institute of Tropical Medicine and Infectious Diseases, Jomo Kenyatta University of Agriculture and Technology, Nairobi 56100, Kenya;School of Public Health, Department of Biomedical Sciences, Maseno University, Kisumu 40100 Kenya

关键词: schistosomiasis;    Kato-Katz;    POC-CCA;    young adults;    soil-transmitted helminths;   

DOI  :  10.3390/tropicalmed3030100

学科分类：传染病学

来源: mdpi

【 摘 要 】

Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students and staff at the Kisumu National Polytechnic in Kisumu, Kenya, using the stool microscopy Kato-Katz (KK) method and the urine point-of-care circulating cathodic antigen (POC-CCA) test. Based on three stools/two KK slides each, in the 208 participants for whom three consecutive stools were obtained, Schistosoma mansoni prevalence was 17.8%. When all 291 individuals were analyzed based on the first stool, as done by the national neglected tropical disease (NTD) program, and one urine POC-CCA assay (n = 276), the prevalence was 13.7% by KK and 23.2% by POC-CCA. Based on three stools, 2.5% of 208 participants had heavy S. mansoni infections (≥400 eggs/gram feces), with heavy S. mansoni infections making up 13.5% of the S. mansoni cases. The prevalence of the soil-transmitted helminths (STH: Ascaris lumbricoides, Trichuris trichiura and hookworm) by three stools was 1.4%, 3.1%, and 4.1%, respectively, and by the first stool was 1.4%, 2.4% and 1.4%, respectively. This prevalence and intensity of infection with S. mansoni in a college setting warrants mass drug administration with praziquantel. This population of young adults is ‘in school’ and is both approachable and worthy of inclusion in national schistosomiasis control and elimination programs.

【 授权许可】

CC BY