Post-injury stretch promotes recovery in a rat model of muscle damage induced by lengthening contractions

The journal of physiological sciences: JPS

Kazue Mizumura¹  Masahiro Sokabe²  Masumi Inoue-Miyazu³  Tomohiro Mori⁴  Nobuhide Agata⁵  Yuta Itoh⁶ 

[1] Aichi Medical College for Physical and Occupational Therapy;Chubu University;Nagoya Gakuin University;Nagoya University Graduate School of Medicine;Nagoya University Hospital;Tokoha University

关键词: Lengthening contractions;    Muscle injury;    Stretch;    Mechanical stimulation;    Regeneration;    Developmental myosin heavy chain;   

DOI  :  10.1007/s12576-017-0553-9

学科分类：生理学

来源: Springer

【 摘 要 】

We investigated the cellular mechanisms and therapeutic effect of post-injury stretch on the recovery process from muscle injury induced by lengthening contractions (LC). One day after LC, a single 15-min bout of muscle stretch was applied at an intensity of 3 mNm. The maximal isometric torque was measured before and at 2–21 days after LC. The myofiber size was analyzed at 21 days after LC. Developmental myosin heavy chain-immunoreactive (dMHC-ir) cells, a marker of regenerating myofibers, were observed in the early recovery stage (2–5 days after LC). We observed that LC-induced injury markedly decreased isometric torque and myofiber size, which recovered faster in rats that underwent stretch than in rats that did not. Regenerating myofiber with dMHC-ir cells was observed earlier in rats that underwent stretch. These results indicate that post-injury stretch may facilitate the regeneration and early formation of new myofibers, thereby promoting structural and functional recovery from LC-induced muscle injury.

【 授权许可】

CC BY