Optogenetics: the new molecular approach to control functions of neural cells in epilepsy, depression and tumors of the central nervous system

American Journal of Cancer Research

Gabriel Alves Bonafé¹  Aurélio Lourenço Diniz²  Jivago Jordão Camargos Ferreira³  Carlos Tadeu Parisi de Oliveira⁴  Bruno Alcântara Manica⁵  Bruno Camporeze⁶ 

[1] Departament of Neurology, Medical School University Pontifical University Catholic of So Paulo (PUCSP), Sorocaba-SP, Brazil;Departament of Neurosurgery, Hospital Santa Paula, So Paulo-SP, Brazil;Departament of Neurosurgery, Universitary Hospital So Francisco de Assis, Bragana Paulista-SP, Brazil;Department of Research and Innovation, Laboratory of Cellular and Molecular Biology, Medical School of ABC (FMABC), Santo Andr-SP, Brazil;Postgraduate Program in Health Science, Department of Neurosurgery, Institute of Medical Assistance of The State Public Servant (IAMSPE), So Paulo-SP, Brazil;Postgraduate Program in Health Science, Laboratory of Cellular and Molecular Biology and Bioactive Compounds, So Francisco University (USF), Bragana Paulista-SP, Brazil

关键词: Optogenetic tools;    light signaling;    epilepsy;    depression;    central nervous system tumors;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

The optogenetic tools have been described as valuable techniques to study neural activity through light stimulation, as well as potential neuromodulator approaches in the management of several central nervous system (CNS) diseases. Since the first bacteriorhodopsin protein described as a single-component light-activated regulator of transmembrane ion flow description, in 1980’s, the focus has been on channel proteins for neurobiology; however, the advances in engineering techniques showed involvement changes in cellular biological behavior in several types of proteins involved in cell cytoskeleton regulation, motility and gene expression. Although the use of this technology has been published in many papers, a question still remains regarding real results and potential clinical applicability in CNS diseases, as well as the publications scarcity that systematically analyses the published results. Lastly, the aim of this review is to discuss the experimental results, molecular mechanisms and potential clinical applications of optogenetic tools in epilepsy and depression treatment, as well as its applicability in the treatment of CNS tumors.

【 授权许可】

CC BY-NC