Topical thermal therapy with hot packs suppresses physical inactivity-induced mechanical hyperalgesia and up-regulation of NGF

The journal of physiological sciences: JPS

Kazue Mizumura¹  Tatsuki Nakagawa²  Shin-ichiro Hiraga³ 

[1] Chubu University;Kanazawa University;Nagoya Gakuin University

关键词: Physical inactivity;    Mechanical hyperalgesia;    Nerve growth factor;    Thermal therapy;    Analgesia;   

DOI  :  10.1007/s12576-017-0574-4

学科分类：生理学

来源: Springer

【 摘 要 】

We focused on the analgesic effect of hot packs for mechanical hyperalgesia in physically inactive rats. Male Wistar rats were randomly divided into four groups: control, physical inactivity (PI), PI + sham treatment (PI + sham), and PI + hot pack treatment (PI + hot pack) groups. Physical inactivity rats wore casts on both hind limbs in full plantar flexed position for 4 weeks. Hot pack treatment was performed for 20 min a day, 5 days a week. Although mechanical hyperalgesia and the up-regulation of NGF in the plantar skin and gastrocnemius muscle were observed in the PI and the PI + sham groups, these changes were significantly suppressed in the PI + hot pack group. The present results clearly demonstrated that hot pack treatment was effective in reducing physical inactivity-induced mechanical hyperalgesia and up-regulation of NGF in plantar skin and gastrocnemius muscle.

【 授权许可】

CC BY