Proliferative changes in the adrenal medulla of aged Chinese native pigs

The Journal of Veterinary Medical Science

Koji UETSUKA¹  James Kenn CHAMBERS²  Takayuki SUZUKI³ 

[1] Laboratory of Animal Health and Hygiene, Department of Food and Life Sciences, College of Agriculture, Ibaraki University, 3-21-1, Chuuo, Ami, Inashiki,Ibaraki 300-0393, Japan;Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657,Japan;Nippon Institute for Biological Science, 9-2221-1 Shin-machi, Ome,Tokyo 198-0024, Japan

关键词: adrenal gland;    hyperplasia;    medulla;    pheochromocytoma;    pig;   

DOI  :  10.1292/jvms.17-0630

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Four aged retired Chinese native pigs, three females and one male, estimated as over 10-year-old, were subjected to autopsy because of infertility due to aging. Grossly, nodular lesions were found bilaterally in the adrenal medulla of all four pigs. Based on the gross and the histopathological findings, they were diagnosed as either medullary nodular hyperplasia or pheochromocytoma. Immunohistochemically, proliferating cells of all these lesions were immuno-positive for chromogranin-A, indicating adrenal medulla-derived. Ultrastructurally, cytoplasmic neurosecretory granules suggestive of secretion were observed in these proliferating cells. There have been only limited numbers of reports on adrenal medullar proliferative changes including pheochromocytoma in pigs. The present cases will provide a valuable information for the characterization of similar changes in animals and human.

【 授权许可】

Unknown