Monitoring cognitive change in multiple sclerosis using a computerized cognitive battery

Multiple Sclerosis Journal – Experimental, Translational and Clinical

LDe Meijer¹ 

关键词: Cognition;    multiple sclerosis;    monitoring;    CogState;    computerized;    Paced Auditory Serial Addition Test;   

DOI  :  10.1177/2055217318815513

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

BackgroundCognitive monitoring that can detect short-term change in multiple sclerosis is challenging. Computerized cognitive batteries such as the CogState Brief Battery can rapidly assess commonly affected cognitive domains.ObjectivesThe purpose of this study was to establish the acceptability and sensitivity of the CogState Brief Battery in multiple sclerosis patients compared to controls. We compared the sensitivity of the CogState Brief Battery to that of the Paced Auditory Serial Addition Test over 12 months.MethodsDemographics, Expanded Disability Status Scale scores, depression and anxiety scores were compared with CogState Brief Battery and Paced Auditory Serial Addition Test performances of 51 patients with relapsing–remitting multiple sclerosis, 19 with secondary progressive multiple sclerosis and 40 healthy controls. Longitudinal data in 37 relapsing–remitting multiple sclerosis patients were evaluated using linear mixed models.ResultsBoth the CogState Brief Battery and the Paced Auditory Seri...

【 授权许可】

CC BY-NC