Expression of some ATP-binding cassette transporters in acute myeloid leukemia

Hematology Reports

Sara Pasquina Pascale¹  Sabrina Coluzzi¹  Michele Pizzuti¹  Immacolata Attolico¹  Roberta Nuccorini¹  Antonella Maria Salvia²  Faustino Bisaccia²  Angela Ostuni²  Flavia Cuviello² 

[1] Department of Hematology, San Carlo Hospital, Potenza;Department of Sciences, University of Basilicata, Potenza

关键词: Acute Myeloid Leukemia;    Multidrug Resistance;    ABC transporters;    ABCC6;   

DOI  :  10.4081/hr.2017.7406

学科分类：血液学

来源: Pagepress

【 摘 要 】

Hematopoietic cells express ATP binding cassette (ABC) transporters in relation to different degrees of differentiation. One of the known multidrug resistance mechanisms in acute myeloid leukemia (AML) is the overexpression of efflux pumps belonging to the superfamily of ABC transporters such as ABCB1, ABCG2 and ABCC1. Although several studies were carried out to correlate ABC transporters expression with drug resistance, little is known about their role as markers of diagnosis and progression of the disease. For this purpose we investigated the expression, by real-time PCR, of some ABC genes in bone marrow samples of AML patients at diagnosis and after induction therapy. At diagnosis, ABCG2 was always down-regulated, while an up regulated trend for ABCC1 was observed. After therapy the examined genes showed a different expression trend and approached the values of healthy subjects suggesting that this event could be considered as a marker of AML regression. The expression levels of some ABC transporters such as ABCC6, seems to be related to gender, age and to the presence of FLT3/ITD gene mutation.

【 授权许可】

CC BY-NC