期刊论文详细信息
Endocrine journal
Effects of linagliptin monotherapy compared with voglibose on postprandial lipid profiles in Japanese patients with type 2 diabetes: linagliptin study of effects on postprandial blood glucose (L-STEP) sub-study 1
Hiroaki Satoh1  Hiroko Chimori2  Yoshio Fujitani3  Yosuke Okada4  Ikuo Inoue5  Akira Kurozumi6  Toshihiko Shiraiwa7  Etsuko Akita8 
[1] Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan;Chimori Medical Clinic, Osaka, Japan;Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan;Department of Metabolism &Division of Diabetes and Endocrinology, Saitama Medical University, Saitama, Japan;First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan;Shiraiwa Medical Clinic, Osaka, Japan;Toyonaka Wakabakai Hospital, Osaka, Japan
关键词: Dipeptidyl peptidase-4 inhibitor;    Type 2 diabetes;    Postprandial dyslipidemia;   
DOI  :  10.1507/endocrj.EJ17-0386
学科分类:内分泌与代谢学
来源: Japan Endocrine Society
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【 摘 要 】

Recently, we reported that linagliptin had equivalent efficacy to voglibose in reducing postprandial blood glucose levels in drug-naïve patients with type 2 diabetes (L-STEP Study). As a sub-study of the L-STEP Study we examined the effect of linagliptin on postprandial lipids profile. Between October 2012 and April 2014, the study enrolled patients with type 2 diabetes mellitus who had inadequate glycemic control. Patients were randomly assigned to either the linagliptin group (5 mg once daily, n = 85) or the voglibose group (0.2 mg/meal thrice daily, n = 71). Meal tolerance tests were performed at baseline (week 0) and endpoint (week 12). The increments in 4-h postprandial triglyceride, remnant lipoprotein cholesterol (RLP-C), and apolipoprotein B48 (ApoB48) from baseline to endpoint in the linagliptin group were lower (p < 0.001, p = 0.025 and p < 0.001). 4-h postprandial ApoB48 at endpoint was lower in the linagliptin group (p = 0.007), and positive correlation was detected between change of ApoB48 and changes in both triglyceride (r = 0.67, p < 0.001) and RLP-C (r = 0.73, p < 0.001) at 4 h. This study revealed that in drug-naïve Japanese patients with relatively mild type 2 diabetes mellitus, linagliptin improves not only postprandial blood glucose level but also levels of lipids such as TG and RLP-C by reducing the ApoB48 level compared with voglibose.

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