Association of total testosterone, free testosterone, bioavailable testosterone and sex hormone–binding globulin with hepatic steatosis and the ratio of aspartate aminotransferase to alanine aminotransferase

Endocrine journal

Haoqiang Wu¹  Yiyi Zhuang²  Kusheng Wu³  Qingtao Yang⁴  Liang Lu⁵ 

[1] 2012 Grade, Students of Seven-Year Clinical Medicine, Shantou University Medical College, Shantou 515041, China;2013 Grade, Students of Five-Year Clinical Medicine, Shantou University Medical College, Shantou 515041, China;Department of Preventive Medicine, Shantou University Medical College, Shantou 515041, China;Department of Urology, the Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China;Laboratory of Pathogenic Biology, Shantou University Medical College, Shantou 515041, China

关键词: Sex hormone–binding globulin;    Total testosterone;    Hepatic steatosis;    Alanine aminotransferase;   

DOI  :  10.1507/endocrj.EJ18-0095

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

Several articles have shown the inverse association between total testosterone (TT) or sex hormone–binding globulin (SHBG) and hepatic steatosis. No articles report associations of TT, SHBG, free testosterone (FT), and bioavailable testosterone (BioT) with aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratios. Therefore, we investigated the associations of TT, FT, BioT and SHBG with hepatic steatosis and AST/ALT ratios. A total of 218 men were enrolled. We diagnosed hepatic steatosis by ultrasound. TT and SHBG showed a reduced risk for hepatic steatosis when analyzed with or without adjusting for age, smoking, alcohol consumption and physical activity. Compared with the lowest quartile, the ORs for hepatic steatosis in the third and fourth quartiles (0.32 [95% CI: 0.14–0.75] and 0.27 [95% CI: 0.10–0.73], respectively) of SHBG were significantly lower after adjustments. The OR for hepatic steatosis in the fourth quartile of TT (0.41 [95% CI: 0.17–0.95]) was significantly lower than in the lowest quartile after adjustments. The mean AST/ALT ratios in men with hepatic steatosis were lower than those without hepatic steatosis (0.83 and 1.04, respectively), due to the elevated ALT levels in hepatic steatosis groups. Furthermore, TT and SHBG were positively associated with AST/ALT ratios with and without adjustments. In conclusion, higher TT and SHBG levels in men are associated with the reduced risk of hepatic steatosis and elevated AST/ALT ratios, independent of age, smoking, alcohol consumption and physical activity.

【 授权许可】

Unknown