Gut microbiota specific signatures are related to the successful rate of bariatric surgery

American Journal of Translational Research

Gracia María Martín-Núñez¹  Isabel Moreno-Indias²  Josep Vidal³  Ana de Holla⁴  Carolina Gutiérrez-Repiso⁵ 

[1] Centro de Investigacin Biomdica en Red de Diabetes y Enfermedades Metablicas Asociadas (CIBERDEM), Barcelona, Spain;Centro de Investigacin Biomdica en Red de Fisiopatologa de la Obesidad y la Nutricin, CIBERobn, Madrid, Spain;Institut dInvestigacions Biomdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain;Obesity Unit, Endocrinology and Nutrition Department, Hospital Clinic Universitari, Villarroel 170, 08036 Barcelona, Spain;Unidad de Gestin Clnica de Endocrinologa y Nutricin del Hospital Virgen de la Victoria, Instituto de Investigacin Biomdica de Mlaga (IBIMA), Universidad de Mlaga, Mlaga, Spain

关键词: Bariatric surgery;    gut microbiota;    RYGB;    cholesterol;    bile acids;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Bariatric surgery (BS) success rates vary in the long-time. A better understanding of weight-loss response may help improve the outcomes of BS. Gut microbiome could be implicated in the successful rate of BS. The aim of the study is to analyze the role of gut microbiome in the successful rate of BS. This is a cross-sectional study of a prospective cohort of 24 patients who underwent gastric bypass. Patients were classified based on excess weight loss (EWL) as: Success (EWL50% at nadir weight and throughout follow-up), Primary Failure (EWL<50% at nadir weight and thereafter), and Weight Regain (EWL>50% at nadir weight, but <50% at last follow-up visit). Gut microbiome analysis was assessed by High Throughput Sequencing. Cholesterol metabolism was shown as the most affected parameter among groups. Studied groups registered minor changes between their gut microbiome abundances, with Butyrivibrio, Lachnospira and Sarcina among them. However, Success group shared a more diverse core microbiome than the other groups. We showed evidence of a possible role of gut microbiome in the cholesterol metabolism, possibly through bile acids, relative to the success or failure of BS outcomes. Acinetobacter and Serratia, from Primary Failure core microbiome, could have implications in its successful rate. Sarcina abundance was presented as the best genera related to the body mass index (BMI) post-surgery. Gut microbiota could mediate, at least partially, the success rate of BS through their interaction with the bile acids milieu. Further studies are necessary to validate this probe of concept.

【 授权许可】

CC BY-NC