Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living Formosan sambar deer (Rusa unicolor swinhoei)

The Journal of Veterinary Medical Science

Yen-Li HUANG¹  Ai-Mei CHANG²  Chen-Chih CHEN³  Ching-Dong CHANG⁴ 

[1] Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, 1, Shuefu Road, Neipu, Pingtung 912, Taiwan, R.O.C.;Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, 1, Shuefu Road, Neipu, Pingtung 912, Taiwan, R.O.C.;Institute of Wildlife Conservation, College of Veterinary Medicine, National Pingtung University of Science and Technology, 1, Shuefu Road, Neipu, Pingtung 912, Taiwan, R.O.C.;Research Center for Animal Biologics, College of Veterinary Medicine, National Pingtung University of Science and Technology, 1, Shuefu Road, Neipu, Pingtung 912, Taiwan, R.O.C.

关键词: cervidae;    formosan sambar deer;    ruminant rhadinovirus;   

DOI  :  10.1292/jvms.17-0477

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

We documented a case of a free-living Formosan sambar deer (Rusa unicolor swinhoei) infected with a newly discovered ruminant Rhadinovirus (RuRv). Non-purulent encephalitis was the primary histological lesion of the sambar deer. We conducted nested PCR to screen for herpesvirus using generic primers targeting the DNA polymerase gene. In addition, we found that DNA polymerase gene of the sambar deer RuRv was present in the macrophage distributed in the Virchow Robin space with histopathologic lesions by chromogenic in-situ hybridization (CISH). The phylogenetic analysis indicated a high similarity between the viral sequence isolated from fallow deer and our case. This result suggests the possibility of cross-species transmission from other exotic Cervidae reservoir to the Formosan sambar deer.

【 授权许可】

Unknown