Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies

The Journal of Veterinary Medical Science

Hiroko YAMASHITA¹  Nozomi SHIWA²  Kazunori KIMITSUKI³  Koki TOMIOKA⁴ 

[1] Department of Microbiology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan;Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23-35-1, Higashi, Towada, Aomori 034-8628, Japan;Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan;Veterinary Research Department, Research Institute for Tropical Medicine, Department of Health, 9002 Research Drive, Filinvest Corporate City, Alabang, Muntinlupa City 1781, Philippines

关键词: Follicle-sinus complex;    FSC;    post-mortem diagnosis;    rabies;   

DOI  :  10.1292/jvms.18-0591

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

In the present study, follicle-sinus complexes (FSCs) were harvested from the muzzle skin of 123 dogs with suspected canine rabies, and the sensitivity and specificity of FSC analysis were compared with those of brain tissue immunohistochemistry analysis. In the FSCs, viral antigen was detected from Merkel cells. Sensitivity was 97.3%, specificity was 100%, and the coefficient κ was 0.88. These results reconfirm that FSCs are very useful for the postmortem diagnosis of canine rabies, and suggest that 5 FSCs can yield results that are almost equivalent to those derived from brain tissue analysis in rabid dogs.

【 授权许可】

Unknown