Prevalence of 16S rRNA methylases in Gram-negative bacteria derived from companion animals and livestock in Japan

The Journal of Veterinary Medical Science

Michiha KON¹  Akira FUKUDA²  Masaru USUI³  Akari KAJINO⁴ 

[1] Department of Veterinary Internal Medicine, Tottori University, Minami 4-101, Koyama-cho, Tottori-Shi, Tottori 680-8553, Japan;Division of Bioresources, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido 001-0020, Japan;Laboratory of Food Microbiology and Food Safety, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan;National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan

关键词: aminoglycoside resistance;    companion animals;    livestock;    16S rRNA methylases;   

DOI  :  10.1292/jvms.19-0144

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

The emergence and spread of aminoglycoside-resistant bacteria are a public health concern. The acquisition of the genes encoding 16S rRNA methylases, such as armA, rmtA, and rmtB, confers high-level resistance to aminoglycosides. However, the prevalence has not been well investigated in Japanese veterinary fields. To determine the prevalence of 16S rRNA methylases in animals, we detected 16S rRNA methylases genes in Gram-negative bacteria from animals. Here, we report the isolation of rmtB amd armA from two of the 446 Escherichia coli (0.5%) and one of the 103 Klebsiella spp. isolates (1.0%) from companion animals, respectively. However, none of the isolations were observed from 2445 E. coli isolates derived from livestock in Japan. The prevalence of 16S rRNA methylases in animals, especially in companion animals, should be carefully monitored in Japanese veterinary fields to avoid the spreading of the genes.

【 授权许可】

Unknown