Cytochrome P450 Genes (CYP2E1 and CYP1A1) Variants and Susceptibility to Chronic Hepatitis B Virus Infection

Indian journal of clinical biochemistry: IJCB

Masomeh Bayani¹  Mohammad Karimi Alivije²  Farhang Babamahmoodi³  Sadegh Fattahi⁴ 

[1] Babol University of Medical Sciences;Imam Reza Hospital;Mazandaran University of Medical Sciences;Pasteur Institute of Iran

关键词: Hepatitis;    Cytochrome P450;    CYP2E1;    CYP1A1;    RFLP;   

DOI  :  10.1007/s12291-017-0698-6

学科分类：过敏症与临床免疫学

来源: Springer

【 摘 要 】

Hepatitis B virus (HBV) infection is a worldwide health concern which is associated with significant morbidity and mortality. Both viral and host factors have a significant effect on infection, replication and pathogenesis of HBV. The aim of this study was to investigate the effect of CYP2E1 and CYP1A1 genetic variants on susceptibility to HBV. 143 individuals including 54 chronic HBV patients and 89 healthy controls were enrolled in the genotyping procedure. rs2031920 and rs3813867 at CYP2E1 as well as rs4646421 and rs2198843 at CYP1A1 loci were studied in all subjects using PCR–RFLP (restriction fragment length polymorphism) analysis. Both variants at CYP2E1 locus were monomorphic in all studied subjects. Genotype frequency of rs4646421 was significantly different between chronic HBV patients and healthy blood donors (P = 0.04, OR 4.31; 95% CI 1.04–17.7). Furthermore, individuals carrying at least one C allele (CC or CT genotypes) for rs4646421 seemed to have a decrease risk of hepatitis in comparison with TT genotype (P = 0.039). Our results showed a relationship between rs4646421 TT genotype (rare genotype) and the risk for developing chronic HBV infection (four times higher). Further studies are needed to examine the role of CYP1A1 polymorphism in susceptibility to chronic HBV infection.

【 授权许可】

CC BY