Disrupt toxicity testing: It’s the dose rate that makes the poison

Toxicology Research and Application

Janis EHulla¹ 

关键词: Adverse outcome pathways;    toxicity testing;    disruptive technologies;    real-time imaging;    dose–response;    Frank R. Lautenberg Chemical Safety for the 21st Century Act;   

DOI  :  10.1177/2397847317723571

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Dimensions of time that are relevant to molecular mechanisms are not incorporated into conventional toxicity testing methodologies. Historically, this was due to technological limitations. These limitations no longer exist. Application of real-time imaging and chemical sensor technologies presents an opportunity to overcome the challenges that have stalled essential transformation of toxicity testing methodology.

【 授权许可】

CC BY