Fundamental aspects of arm repair phase in two echinoderm models

Developmental biology

Yousra Ben Khadra^3¹  Pedro Martinez^5,6²  Anne Zakrzewski^4³  Cinzia Ferrario^1,2,7⁴  Francesco Bonasoro^1,7⁵  Graziano Colombo^1⁶  Anna Czarkwiani^4⁷ 

[1] Center for Complexity&Biosystems, Dipartimento di Fisica, Università degli Studi di Milano, via Celoria, 16, 20133 Milano, Italy^2;Departament de Genètica, Microbiologia I Estadística, Universitat de Barcelona, Av. Diagonal, 645, E-08028 Barcelona, Spain^5;Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, WC1E 6BT London, United Kingdom^4;Dipartimento di Bioscienze, Università degli Studi di Milano, via Celoria, 26, 20133 Milano, Italy^1;Dipartimento di Scienze e Politiche Ambientali, Università degli Studi di Milano, via Celoria, 2, 20133 Milano, Italy^7;ICREA (Institut Català de Recerca i Estudis Avancats), Barcelona, Spain^6;Laboratoire de Recherche, Génétique, Biodiversité et Valorisation des Bioressources, Institut Supérieur de Biotechnologie de Monastir, Université de Monastir, Monastir, Tunisia^3

关键词: Starfishes;    Brittle stars;    Emergency reaction;    Wound healing;    Collagen;    Immune/inflammatory response;   

DOI  :  10.1016/j.ydbio.2017.09.035

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Regeneration is a post-embryonic developmental process that ensures complete morphological and functional restoration of lost body parts. The repair phase is a key step for the effectiveness of the subsequent regenerative process: in vertebrates, efficient re-epithelialisation, rapid inflammatory/immune response and post-injury tissue remodelling are fundamental aspects for the success of this phase, their impairment leading to an inhibition or total prevention of regeneration. Among deuterostomes, echinoderms display a unique combination of striking regenerative abilities and diversity of useful experimental models, although still largely unexplored.

【 授权许可】

CC BY