Structural aspects of Alzheimer’s disease immunotherapy targeted against amyloid-beta peptide

Bratislava Medical Journal

O. Cehlar¹ 

关键词: Alzheimer’s disease;    amyloid beta;    immunotherapy;    antibody-amyloid complex;   

DOI  :  10.4149/BLL_2018_037

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

Alzheimer’s disease is the most prominent neurodegenerative disease and has no efficient therapies available so far. Immunotherapy against amyloid-β (Aβ) peptide is one of the currently tested therapeutic approaches. Here we have reviewed the available structural knowledge about antibodies tested as passive anti-Aβ immunotherapy in clinical trials. The therapeutic anti-Aβ antibodies differ in their epitope specificity and in recognition and affinity to different Aβ species present in vivo (Tab. 1, Fig. 1, Ref. 17).

【 授权许可】

CC BY