The role of proteinuria, paricalcitol and vitamin D in the development of post-transplant diabetes mellitus

Bratislava Medical Journal

I. Dedinska¹ 

关键词: post-transplant diabetes mellitus;    proteinuria;    vitamin D;    paricalcitol;    kidney transplantation.;   

DOI  :  10.4149/BLL_2018_073

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

INTRODUCTION: Post-transplant diabetes mellitus (PTDM) occurs most frequently during the first year after transplantation. We focused on parameters of calcium-phosphate metabolism and proteinuria as possible new risk factors for PTDM after kidney transplantation. MATERIALS AND METHODS: We have prospectively identified risk factors for post-transplant diabetes mellitus with follow-up of 12 months in a set of 167 patients after kidney transplantation. Patients with diabetes mellitus type 1 and type 2 as well as patients using ciclosporin A or mTOR inhibitor have been excluded from the monitoring. From the perspective of immunosuppression it was a homogeneous set of patients. RESULTS: We identified the following independent risk factors for PTDM in our set: average proteinuria > 0.300 g/24 h (HR 3.0785, (95 % CI 1.6946–5.5927), p=0.0002), level of vitamin D

【 授权许可】

CC BY