Immunosenescence – the role in the immunotherapy of older population

Bratislava Medical Journal

M. Prcina¹ 

关键词: immunosenescence;    vaccination;    neurodegeneration;   

DOI  :  10.4149/BLL_2018_040

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

With ageing of their populations, many societies are challenged with serious systemic diseases. One of the causes of these diseases could be the age-related defects in immune system termed immunosenescence. Immunosenescence is characterized by accumulation of memory and non-functional immune cells, impaired signalling due to restricted repertoire of receptors, overall pro-inflammatory environment and complete dysregulation of the immune system. Consequences of immunosenescence are serious, older people are not able to respond to new stimuli, including infections and vaccinations and are more prone to oncologic, neurodegenerative and autoimmune diseases (Ref. 49).

【 授权许可】

CC BY