The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis

Developmental biology

Lindsay E. Parrie¹ 

[1] Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States

关键词: Prion;    Proliferation;    Differentiation;    Axon targeting;   

DOI  :  10.1016/j.ydbio.2018.03.012

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

The cellular prion protein (PrPC) has been associated with diverse biological processes including cell signaling, neurogenesis, and neuroprotection, but its physiological function(s) remain ambiguous. Here we determine the role of PrPC in adult neurogenesis using the olfactory system model in transgenic mice. Olfactory sensory neurons (OSNs) within the olfactory sensory epithelium (OSE) undergo neurogenesis, integration, and turnover even into adulthood.

【 授权许可】

CC BY