JNK and JAK/STAT signalling are required for inducing loss of cell fate specification during imaginal wing discs regeneration in Drosophila melanogaster

Developmental biology

Sara Ahmed-de-Prado^1¹  Sandra Diaz-Garcia^2,1² 

[1] Centro de Biología Molecular “Severo Ochoa”, CSIC/UAM, C/Nicolás Cabrera 1, Madrid 28049, Spain^1;University of California, San Diego Section of Cell&Developmental Biology, La Jolla, CA 92093-0349, USA^2

关键词: Regeneration;    JNK signalling;    JAK/STAT signalling;    Imaginal discs;    Drosophila;   

DOI  :  10.1016/j.ydbio.2018.05.021

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

The regenerative process after tissue damage relies on a variety of cellular responses that includes compensatory cell proliferation and cell fate re-specification. The identification of the signalling networks regulating these cellular events is a central question in regenerative biology. Tissue regeneration models in Drosophila have shown that two of the signals that play a fundamental role during the early stages of regeneration are the c-Jun N-terminal kinase (JNK) and JAK/STAT signalling pathways. These pathways have been shown to be required for controlling regenerative proliferation, however their contribution to the processes of cellular reprogramming and cell fate re-specification that take place during regeneration are largely unknown. Here, we present evidence for a previously unrecognised function of the cooperative activities of JNK and JAK/STAT signalling pathways in inducing loss of cell fate specification in imaginal discs. We show that co-activation of these signalling pathways induces both the cell fate changes in injured areas, as well as in adjacent cells. We have also found that this function relies on the activity of the Caspase initiator encoded by the gene dronc.

【 授权许可】

CC BY