Fibrin-associated large B-cell lymphoma: first case report within a cerebral artery aneurysm and literature review

BMC Cancer

  ^{1    2    2    3    4    5    6    6    7} 

[1] 0000 0004 0486 1959, grid.413179.9, Pathology Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy;0000 0004 1757 3630, grid.9027.c, Hematology Unit, CREO, Azienda Ospedaliera di Perugia, University of Perugia, Perugia, Italy;0000 0004 1757 3630, grid.9027.c, Pathology Unit, Ospedale di Terni, University of Perugia, Perugia, Italy;0000 0004 1760 8127, grid.414396.d, Hematology Unit, Ospedale di Belcolle, Viterbo, Italy;0000 0004 1760 8127, grid.414396.d, Pathology Unit, Ospedale di Belcolle, Viterbo, Italy;Pathology Unit, Azienda Unità Sanitaria Locale-IRCCS Reggio Emilia, Reggio Emilia, Italy;Surgical Oncology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy;0000000121697570, grid.7548.e, Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy;

关键词: Fibrin;    B-cell;    Lymphoma;    Epstein-Barr virus;   

DOI  :  10.1186/s12885-019-6123-1

来源: publisher

【 摘 要 】

BackgroundFibrin-associated diffuse large B-cell lymphoma (FA-DLBCL) is a rare Epstein-Barr virus (EBV) positive lymphoproliferative disorder included in the current World Health Organization (WHO) classification. It arises within fibrinous material in the context of hematomas, pseudocysts, cardiac myxoma or in relation with prosthetic devices. In these clinical settings the diagnosis requires an high index of suspicion, because it does not form a mass itself, being composed of small foci of neoplastic cells. Despite overlapping features with diffuse large B-cell lymphoma associated with chronic inflammation, it deserves a separate classification, being not mass-forming and often following an indolent course.Case presentationA 64-year-old immunocompetent woman required medical care for cerebral hemorrhage. Computed Tomography (CT) angiography identified an aneurysm in the left middle cerebral artery. A FA-DLBCL was incidentally identified within thrombotic material in the context of the arterial aneurysm. After surgical removal, it followed a benign course with no further treatment.ConclusionsThe current case represents the first report of FA-DLBCL identified in a cerebral artery aneurysm, expanding the clinicopathologic spectrum of this rare entity. A complete literature review is additionally made.

【 授权许可】

CC BY