Mesonephric adenocarcinoma of the cervix: a case report with a three-year follow-up, lung metastases, and next-generation sequencing analysis

Diagnostic Pathology

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[1] 0000 0004 0374 9308, grid.414834.e, Facultad de Ciencias Médicas de la Salud y la Vida, Escuela de Medicina, Universidad Internacional del Ecuador. Servicio de Patología, Hospital Metropolitano, Av. Mariana de Jesús s/n y Nicolás Arteta, Quito, Ecuador;0000 0004 0374 9308, grid.414834.e, Servicio de Patología Hospital Metropolitano, Quito, Ecuador;grid.442217.6, Facultad de Ciencias Médicas de la Salud y la Vida, Escuela de Medicina, Docencia y Departamento de Investigación, Universidad Internacional del Ecuador, Quito, Ecuador;

关键词: Cervix;    Mesonephric carcinoma;    Mesonephric adenocarcinoma;    CTNNB1;    KRAS;    1q gain;   

DOI  :  10.1186/s13000-019-0847-8

来源: publisher

【 摘 要 】

BackgroundMesonephric adenocarcinoma (MNAC) is a rare tumor of the female genital tract, which originates from mesonephric duct remnants. Its diagnosis is pathologically challenging, because MNAC may exhibit a mixture of morphological patterns that complicates the differential diagnosis.Case presentationThe patient in this case was a 48-year-old woman with a polypoid mass protruding into the endocervical canal. The patient underwent a total hysterectomy outside the institution. During biopsy, the mass showed a cerebroid aspect. Histological study revealed a tumor with a predominantly tubular and ductal growth pattern. The immunoprofile showed negative staining for calretinin, carcinoembryonic antigen (CEAm), estrogen receptors (ER), and progesterone receptors (PR), and positive staining for CD10, p16, and PAX2. The Ki-67 score was 46%. Using a next-generation sequencing assay, we documented genomic alterations in KRAS and CTNNB1, low tumor mutation burden (TMB), and an absence of microsatellite instability. In addition, gain of the long arm of chromosome 1 (1q) was also documented using chomogenic in situ hybridization (CISH). Three years later, the patient presented pulmonary nodules in the lingula and left basal lobe that were resected by thoracotomy. The histopathologic study of the pulmonary nodules confirmed the presence of metastases.ConclusionCarcinomas of mesonephric origin are among the rarest subtypes of cervical tumors. We report the first case of mesonephric adenocarcinoma of the cervix with lung metastases showing a CTNNB1 gene mutation.

【 授权许可】

CC BY