Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition

Journal of the American Heart Association

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[1] Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC;University of North Carolina McAllister Heart Institute, Chapel Hill, NC;Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC;Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC;University of North Carolina McAllister Heart Institute, Chapel Hill, NC;Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC;Division of Cardiology, University of North Carolina School of Medicine, Chapel Hill, NC;University of North Carolina McAllister Heart Institute, Chapel Hill, NC;Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC;Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC;University of North Carolina McAllister Heart Institute, Chapel Hill, NC;

关键词: antineoplastic agents;    cardiomyopathy;    cardiotoxicity;    protein kinase inhibitors;    proteomics;   

DOI  :  10.1161/JAHA.117.006635

来源: publisher

【 授权许可】

Unknown