Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis

Pharmacology Research & Perspectives

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[1] Clinical Pharmacology, Early Clinical Development, Pfizer Inc., Cambridge, UK;Compound Safety Prediction, Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut;Global Biometrics and Data Management, Pfizer Inc., Cambridge, UK;Investigative Toxicology, Drug Safety Research and Development, Pfizer Inc., Groton, Connecticut;Medicine Design, Primary Pharmacology Group, Pfizer Inc., Groton, Connecticut;Neusentis Research Unit, Pfizer Inc., Durham, North Carolina;Safety Biomarkers, Drug Safety Research and Development, Pfizer Inc., Groton, Connecticut;

关键词: bile acid conjugation status;    bile acid homeostasis;    BSEP;    hepatotoxicity;    PF;   

DOI  :  10.1002/prp2.467

来源: publisher

【 授权许可】

Unknown