Analysis of common targets for circular RNAs

BMC Bioinformatics

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[1] 0000 0004 0532 3255, grid.64523.36, Department of Physiology, National Cheng Kung University, 70101, Tainan, Taiwan;0000 0004 0532 3749, grid.260542.7, Department of Plant Pathology, College of Agriculture and Natural Resources, National Chung Hsing University, 40227, Taichung, Taiwan;0000 0000 9263 9645, grid.252470.6, Department of Biotechnology, Asia University, 41354, Taichung, Taiwan;0000 0004 0532 3749, grid.260542.7, Institute of Biochemistry, College of Life Sciences, National Chung Hsing University, 40227, Taichung, Taiwan;0000 0004 0532 3749, grid.260542.7, Program in Translational Medicine, College of Life Sciences, National Chung Hsing University, 40227, Taichung, Taiwan;0000 0004 0532 3749, grid.260542.7, Rong Hsing Research Center for Translational Medicine, College of Life Sciences, National Chung Hsing University, 40227, Taichung, Taiwan;0000 0004 0532 3749, grid.260542.7, Bachelor Program of Biotechnology, College of Agriculture and Natural Resources, National Chung Hsing University, 40227, Taichung, Taiwan;0000 0004 0638 9256, grid.411645.3, Department of Radiation Oncology, Chung Shan Medical University Hospital, 40201, Taichung, Taiwan;0000 0004 0532 2041, grid.411641.7, School of Medicine, Chung Shan Medical University, 40201, Taichung, Taiwan;

关键词: Circular RNA;    microRNA;    Common targets;    miRNA sponge;   

DOI  :  10.1186/s12859-019-2966-3

来源: publisher

【 摘 要 】

BackgroundThe studies of functions of circular RNAs (circRNAs) are heavily focused on the regulation of gene expression through interactions with multiple miRNAs. However, the number of predicted target genes is typically overwhelming due to the synergistic complexity caused by two factors ─ the binding of multiple miRNAs to a circRNA and the existence of multiple targets for each miRNA. Analysis of common targets (ACT) was designed to facilitate the identification of potential circRNA targets.ResultsWe demonstrated the feasibility of the proposed feature/measurement to assess which genes are more likely to be regulated by circRNAs with given sequences by calculating the level of co-regulation by multiple miRNAs. The web service is made freely available at http://lab-x-omics.nchu.edu.tw/ACT_Server.ConclusionsACT allows users to identify potential circRNA-regulated genes and their associated pathways for further investigation.

【 授权许可】

CC BY