Diazepam is not a direct allosteric modulator of α1‐adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase‐4

Pharmacology Research & Perspectives

  ^{1    2    3    3    3    4    4    5    6} 

[1] Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Vic, Australia;The Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Vic, Australia;School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Vic, Australia;The Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Vic, Australia;The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic, Australia;The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic, Australia;Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Vic, Australia;The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic, Australia;Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Vic, Australia;The Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Vic, Australia;The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic, Australia;School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Vic, Australia;

关键词: α adrenergic receptors;    α‐adrenoceptors;    allosteric modulator;    benzodiazepines;    GPR68;    phosphodiesterase;    thermostabilized receptor;   

DOI  :  10.1002/prp2.455

来源: publisher

【 授权许可】

Unknown